Advanced Glycation End-products (AGEs) are produced by a non-enzymatic reaction between sugar and amino groups of proteins, lipids and nucleic acids in both diabetic and non-diabetic conditions (1). AGEs can be classified based on chemical structure (fluorescent or non-fluorescent) or molecular weight (low or high molecular weight) (2). Extracellular and intracellular accumulation of AGEs trigger their pathological effects via two pathways: disruption of protein function and activation of receptor for AGE (RAGE) (3). It has been established that AGE accumulation contributes to a wide range of diseases including metabolic, reproductive, neurodegenerative and cardiovascular (4).